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Enter up to 375 characters add a description to your widget: This study looked at the role of vitamin D receptor (VDR) polymorphisms in a Japanese population, and the association between VDR genotype and breast cancer survival, using a case–control design. In this population, there was a high level of sun exposure with the ability to maintain or increase vitamin D levels, and the prevalence of vitiligo was significantly lower. The authors report that association between circulating level and survival is likely to be explained by increased circulating VDR levels.
The VDR is an intracellular protein that expressed on the outer surface of cells. role VDR in immune response has been identified in both normal (in patients with rheumatoid arthritis) and malignancy (the ability to maintain plasma vita-min and reduce vita-min-dependent HIV transcription). The finding of increased circulating vitamin D levels after prolonged supplementation of vitamin D is consistent with the notion that this protein plays a role in immunity.
The authors then performed a case control study of 10,527 Japanese men and women aged 20–79 years, who were part of the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC study). Participants in the cohort who had a diagnosis of breast cancer, or who Where can i buy azithromycin 500mg tablets were still alive as at the date of completion study, were invited to be re-investigated (the Japanese Breast Cancer Prevention Study [JBCPS]). They included non-small cell and non-Hodgkin's lymphoma cases as well women with benign breast disease and histories of early mortality (n = 5,945)
To identify the relationship between circulating levels of vitamin D and survival, they employed a case–control study design where participants with a diagnosis of breast cancer (either singly or in combination with other causes) were invited to be re-investigated for their plasma levels of vitamin D. A second group, recruited later as part of the Japanese Breast Cancer Prevention Study (JBCPS), for whom the authors obtained a complete set of information on the participant's age, race, body mass index (BMI), smoking, post-treatment serum levels of vitamin D (VDR genotype and other covariates), death dates were included in the analysis. analysis controlled for age, race, BMI, previous mortality, prior recurrence of breast cancer, cancer detection and treatment, treatment recurrence, self-rated health, vitamin D status, and other possible confounders.
To assess the association between distribution and plasma levels of vitamin D and the risk of breast cancer, they performed a nested, case–control analysis in the Japanese Breast Cancer Prevention Study with the use of data collected in 1995.
To detect the association between VDR genotype and breast cancer survival, they used a case–control study design in male healthy Japanese population, which participants were invited to participate in the JACC study between 1993 and 2006 (JACC study). Participants were matched to with breast cancer using date of birth at entry to the study and, thus, included in the analyses as cases. study period comprised 9 years of follow-up. The number cancers diagnosed was not restricted to the breast and all cancers combined, as the investigators sought to obtain as representative the population in anti fungal cream to buy which study was conducted.
The authors examined role of circulating level vitamin D on the risk of breast cancer with a nested case–control analysis. They also undertook a case–control study of healthy Japanese men, to ascertain the association between circulating D-25 levels and the risk of developing breast cancer.
In addition to this nested case–control study design, they conducted a case–control study of healthy Japanese women to ascertain the association between circulating levels of vitamin D and the risk of developing breast cancer. The study was supported by Japan Can you buy cialis online in australia Society for the Promotion of Science Grant-in-Aid for Scientific Research (GSK), grant number 4892-08.
Overall, the results showed that, while VDR genotyping was not associated with the risk of breast cancer diagnosis, VDR genotype was associated with lower overall risk of developing breast cancer, while plasma levels of vitamin D were inversely associated with survival.
A possible mechanism by which vitamin D plays a role in reducing breast cancer risk appears to relate the mechanism by which it prevents rickets in children.
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